Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists

US9556248B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Jennifer R. Cochran · Stanford, US
• Douglas Jones · Newton, US
• Ping-Chuan Tsai · Fremont, US

Key dates

• Filing date: Mar 21, 2011
• Grant date: Jan 31, 2017
• Expiry date: Mar 21, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.