Patent · US Active

Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages

US9556273B2 · kind B2 · utility

0Cited by

4References

21Claims

0Family size

Assignees

VIB VZW · BE
VRIJE UNIVERSITEIT BRUSSEL · BE

Inventors

Jo Van Ginderachter · Ninove, BE
Patrick De Baetselier · Berchem, BE
Nick Devoogdt · Zemst, BE
Tony Lahoutte · Ganshoren, BE
Damya Laoui · Limal, BE
Kiavash Movahedi · Frankfurt am Main, DE
Geert Raes · Sint-Genesius-Rode, BE
Steve Schoonooghe · Kessel-Lo, BE

Key dates

Filing date	Mar 15, 2013
Grant date	Jan 31, 2017
Priority date	—
Expiry date	Mar 15, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/569
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.