Patent · US Active

Nucleic acids for down-regulation of gene expression

US9556433B2 · kind B2 · utility

2Cited by

0References

21Claims

0Family size

Assignees

UNIVERSITÉ DE GENVE · CH
University of Pretoria · ZA

Inventors

Karl-Heinz Krause · Neuenrade, DE
Renier Myburgh · Zürich, CH
Patrick Salmon · Arenthon, FR

Key dates

Filing date	Sep 13, 2013
Grant date	Jan 31, 2017
Priority date	—
Expiry date	Sep 13, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2330/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.