Carrier-linked treprostinil prodrugs

US9561287B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA A/S · DK

Inventors

• Ulrich Hersel · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Torben Lessmann · Neustadt an der Weinstraße, DE
• Nicola Bisek · Heidelberg, DE
• Guillaume Maitro · Mannheim, DE
• Kennett Sprogøe · Rudegård, DK
• Thomas Wegge · Heidelberg, DE
• Oliver Keil · Glienicke, DE
• Joachim Zettler · Heidelberg, DE

Key dates

• Filing date: Aug 10, 2012
• Grant date: Feb 7, 2017
• Expiry date: Nov 14, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).