Antifouling heparin coatings

US9561309B2 · kind B2 · utility

Assignee

• Advanced Cardiovascular Systems, Inc. · US

Inventors

• Thierry Glauser · Redwood City, US
• Eugene T. Michal · San Francisco, US
• Charles D. Claude · Santa Clara, US
• Stephen D. Pacetti · San Jose, US

Key dates

• Filing date: May 27, 2004
• Grant date: Feb 7, 2017
• Expiry date: Mar 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L1/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.