Patent · US Active

(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

US9562014B2 · kind B2 · utility

1Cited by

7References

17Claims

0Family size

Assignee

MALLINCKRODT LLC · US

Inventors

Bobby N. Trawick · Florissant, US
David W. Berberich · Saint Peters, US
Christopher W. Grote · Webster Groves, US

Key dates

Filing date	Dec 22, 2010
Grant date	Feb 7, 2017
Priority date	—
Expiry date	Mar 19, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D489/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.