Methods of inhibiting complement C4 activation with anti-complement C1s antibodies

US9562092B2 · kind B2 · utility

Assignee

• True North Therapeutics, Inc. · US

Inventors

• Peter Van Vlasselaer · Sunnyvale, US
• Graham Parry · South San Francisco, US
• Nancy E. Stagliano · South San Francisco, US
• Sandip Panicker · South San Francisco, US

Key dates

• Filing date: Nov 4, 2015
• Grant date: Feb 7, 2017
• Expiry date: Nov 4, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.