Systems for treating pulmonary infections

US9566234B2 · kind B2 · utility

Assignee

• Insmed Incorporated · US

Inventors

• Walter Perkins · Ewing Township, US
• Vladimir Malinin · Bound Brook Junction, US
• Xingong Li · Cranbury, US
• Brian S. Miller · Burlingame, US
• Dominique Seidel · Munich, DE
• Philipp Holzmann · Ascholding, DE
• Harald Schulz · Kammeltal, DE
• Michael L. Hahn · Fort Collins, US

Key dates

• Filing date: May 21, 2013
• Grant date: Feb 14, 2017
• Expiry date: Jan 18, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2207/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.