Cyclic peptides and use as medicines

US9566312B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Jiping Fu · Danville, US
• Subramanian Karur · Dublin, US
• Xiaolin Li · San Diego, US
• Peichao Lu · Pleasant Hill, US
• Wosenu Mergo · Oakland, US
• Alexey Rivkin · Emeryville, US
• Zachary K. Sweeney · Redwood City, US
• Meiliana Tjandra · Dublin, US
• Andrew Weiss · San Francisco, US
• Aregahegn Yifru · Benicia, US

Key dates

• Filing date: May 20, 2015
• Grant date: Feb 14, 2017
• Expiry date: May 20, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/645
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I;or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.