Sustained nitric oxide release coating using diazeniumdiolate-doped polymer matrix with ester capped poly(lactic-co-glycolic acid) additive

US9566372B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Hitesh Handa · Athens, US
• Mark E. Meyerhoff · Ann Arbor, US
• Robert H. Bartlett · Ann Arbor, US
• Elizabeth J. Brisbois · Athens, US
• Lahdan Refahiyat · Ann Arbor, US

Key dates

• Filing date: Sep 25, 2013
• Grant date: Feb 14, 2017
• Expiry date: Sep 25, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/802
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.