Primary carboxamides as BTK inhibitors

US9567339B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Dominique Bonafoux · Saint Louis, US
• Heather Davis · Haverhill, US
• Kristine E. Frank · Portage, US
• Michael Friedman · Jerusalem, IL
• J. Martin Herold · Cambridge, US
• Michael Z. Hoemann · Marlborough, US
• Raymond Huntley · Albany, US
• Augustine Osuma · Lindenhurst, US
• George S. Sheppard · Wilmette, US
• Gagandeep Somal · Ashland, US
• Jennifer Van Camp · Ann Arbor, US
• Stacy A. Van Epps · Ashland, US
• Anil Vasudevan · Union Grove, US
• Grier A. Wallace · Sterling, US
• Lu Wang · Worcester, US
• Zhi Wang · Philadelphia, US
• Noel S. Wilson · Kenosha, US
• Xiangdong Xu · Gurnee, US

Key dates

• Filing date: Jun 26, 2014
• Grant date: Feb 14, 2017
• Expiry date: Jun 26, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of Formula (I)pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.