Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom
US9567606B2 · kind B2 · utility
1Cited by
2References
16Claims
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Key dates
| Filing date | Feb 14, 2013 |
| Grant date | Feb 14, 2017 |
| Priority date | — |
| Expiry date | Jul 16, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.