Drug delivery system and method of treatment of vascular diseases using photodynamic therapy

US9572795B2 · kind B2 · utility

Assignee

• Abbott Cardiovascular Systems, Inc. · US

Inventors

• Syed F. A. Hossainy · Fremont, US
• Dariush Davalian · San Jose, US
• Mikael Trollsas · San Jose, US
• John Stankus · Plano, US
• Yuet Mei Khong · Sunnyvale, US
• Jinping Wan · Sunnyvale, US

Key dates

• Filing date: Aug 10, 2012
• Grant date: Feb 21, 2017
• Expiry date: Apr 12, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2025/1086
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.