ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2
US9572879B2 · kind B2 · utility
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Key dates
| Filing date | Jan 4, 2013 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Jan 4, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
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