Devices and methods for modulation of bone erosion
US9572983B2 · kind B2 · utility
45Cited by
247References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 26, 2013 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Sep 5, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/36175
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.