Process for preparing benzothiazepines from gamma-aminoalkylbenzenes
US9573914B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Dec 23, 2013 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Jan 21, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula:by reacting a [2-(acylaminoethyl)thio]arene of formulawith an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formulathen treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.