Heteroaromatic compounds as PI3 kinase modulators and methods of use
US9573953B2 · kind B2 · utility
1Cited by
11References
15Claims
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Key dates
| Filing date | Feb 15, 2014 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Feb 22, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.