Methods for preparing SGLT2 inhibitors

US9573959B2 · kind B2 · utility

Assignee

• MSD INTERNATIONAL GMBH · CH

Inventors

• Steven J. Brenek · New York, US
• Stephane Caron · Groton, US
• Jade Douglas Nelson · Holland, US
• Mark E. Webster · Kokomo, US
• Rodney Matthew Weekly · New York, US

Key dates

• Filing date: Mar 10, 2014
• Grant date: Feb 21, 2017
• Expiry date: Mar 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to methods for preparing a sodium-glucose transporter 2 (SGLT2) inhibitor, a cocrytalline SGLT2 and (S)-5-oxopyrrolidine-2-carboxylic acid (L-PGA) complex, and intermediates useful in the preparation of the said SGLT2 inhibitor.