Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders

US9573983B2 · kind B2 · utility

Assignee

• University of Kansas · US

Inventors

• Teruna J. Siahaan · Lawrence, US
• Prakash Manikwar · Lawrence, US
• Paul Kipkemboi Kiptoo · Lexington, US
• Ahmed Badawi · Overland Park, US
• Barlas Buyuktimkin · Lawrence, US
• John M. Stewart · Lawrence, US

Key dates

• Filing date: Jan 4, 2013
• Grant date: Feb 21, 2017
• Expiry date: Dec 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune disorders in a subject. The present disclosure provides compounds including a modified I-domain peptide having two or more modified lysine residues and two or more signal 1 moieities conjugated to the modified lysine residues of the I-domain peptide and methods of using an making the compounds.