Patent · US Active

Graft polymers for enhanced intracellular delivery of antisense molecules

US9574041B2 · kind B2 · utility

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Key dates

Filing dateFeb 23, 2015
Grant dateFeb 21, 2017
Priority date—
Expiry dateFeb 23, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC08G81/025
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such polymers may comprise an anionic graft polymer comprising an anionic polymer backbone with pendant carboxylic acid groups and pendant chains comprising amphipathic or hydrophilic polymers covalently bonded to a portion of said pendant carboxylic acid groups. Antisense molecule delivery vectors comprising such polymers in combination with cationic agents for delivery of antisense molecules are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.