Enzymatic encoding methods for efficient synthesis of large libraries
US9574189B2 · kind B2 · utility
18Cited by
108References
38Claims
0Family size
Assignee
Inventors
- Thomas Franch
- Mikkel Dybro Lundorf
- Søren Jacobsen
- Eva Kampmann Olsen
- Anne Lee Andersen
- Anette Holtmann
- Anders Holm Hansen
- Anders Malling Sørensen
- Anne Goldbech
- Daen de Leon
- Ditte Kievsmose Kaldor
- Frank Abildgaard Sløk
- Gitte Nystrup Husemoen
- Johannes Dolberg
- Kim Birkebæ Jensen
- Lene Pedersen
- Mads Nørregaard-Madsen
- Michael Anders Godskesen
- Sanne Schrøder Glad
- Søren Neve
- Thomas Thisted
- Tine Titilola Akinleminu Kronborg
- Christian Klarner Sams
- Jakob Felding
- Per-Ola Freskgard
- Alex Haahr Gouliaev
- Henrik Pedersen
Key dates
| Filing date | Dec 1, 2006 |
| Grant date | Feb 21, 2017 |
| Priority date | — |
| Expiry date | Aug 21, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.