Method of producing lipid nanoparticles for drug delivery
US9579338B2 · kind B2 · utility
4Cited by
9References
23Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 5, 2012 |
| Grant date | Feb 28, 2017 |
| Priority date | — |
| Expiry date | Nov 5, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.