Multispecific and multivalent binding proteins and uses thereof

US9580509B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• Nazzareno Dimasi · Gaithersburg, US
• Ryan Fleming · Gaithersburg, US
• Binyam Bezabeh · Gaithersburg, US
• Changshou Gao · Potomac, US
• Antonio Digiandomenico · Gaithersburg, US
• Paul Warrener · Seattle, US
• Charles K. Stover · Gaithersburg, US
• Bret Sellman · Rochester, US
• Mladen Tomich · New York, US
• Reena Varkey · Gaithersburg, US
• Partha S. Chowdhury · Gaithersburg, US
• Ralph Minter · Cambridge, GB
• Sandrine Guillard · Cambridge, GB
• Steven Rust · Cambridge, GB
• Vignesh Venkatraman · Cambridge, GB

Key dates

• Filing date: Nov 6, 2012
• Grant date: Feb 28, 2017
• Expiry date: Nov 6, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.