Thermally-activated self-immolative materials

US9580553B2 · kind B2 · utility

Assignees

• University of Washington through its Center for Commercialization · US
• Pacific Lutheran University · US

Inventors

• Andrew J. Boydston · Middleton, US
• Neal A. Yakelis · Tacoma, US
• Ronald J. Berenson · Mercer Island, US
• Derek C. Church · Seattle, US
• Gregory Isaac Peterson · Tacoma, US
• Michael Byrnes Larsen · Seattle, US

Key dates

• Filing date: Dec 9, 2013
• Grant date: Feb 28, 2017
• Expiry date: Dec 9, 2033

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.