P13K pathway mutations in cancer

US9580750B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Donald William Parsons · Ellicott City, US
• Tian-Li Wang · Baltimore, US
• Yardena Samuels · Potomac, US
• Alberto Bardelli · Baltimore, US
• Christopher Lengauer · Noisy-le-Roi, FR
• Victor Velculescu · Dayton, US
• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US

Key dates

• Filing date: May 23, 2006
• Grant date: Feb 28, 2017
• Expiry date: Feb 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.