Adenosine receptor agonists and antagonists to modulate T cell responses
US9585957B2 · kind B2 · utility
5Cited by
2References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2008 |
| Grant date | Mar 7, 2017 |
| Priority date | — |
| Expiry date | Sep 28, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.