Rapidly disintegrating films for delivery of pharmaceutical or cosmetic agents
US9585961B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 2012 |
| Grant date | Mar 7, 2017 |
| Priority date | — |
| Expiry date | Jul 14, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides disintegratable films containing a mixture of high molecular weight and low molecular weight water soluble components; and a pharmaceutically or cosmetically active ingredient. Optionally, the films contain a starch component, a glucose component, a filler, a plasticizer and/or humectant. The films are preferably in the form of a mucoadhesive monolayer having a thickness sufficient to rapidly disintegrate in the oral environment and release the active ingredient without undue discomfort to the oral mucosa. The monolayer can be cut to any desired size or shape to provide conveniently useable unit dosage forms for administration to oral or other mucosal surfaces for human pharmaceutical, cosmetic, or veterinary applications. The invention further provides methods of administering the film compositions by placing the composition into, for example, the oral cavity for a sufficient period of time to permit the film to disintegrate and release the active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.