Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

US9586888B2 · kind B2 · utility

Assignee

• Sunovion Pharmaceuticals Inc. · US

Inventors

• Liming Shao · Lincoln, US
• Fengjiang Wang · Northborough, US
• Scott Malcolm · Southborough, US
• Michael Charles Hewitt · Somerville, US
• Jianguo Ma · Natick, US
• Seth Ribe · Worcester, US
• Mark A. Varney · Laguna Niguel, US
• Una Campbell · Marlborough, US
• Sharon Engel · Hudson, US
• Larry Wendell Hardy · Sturbridge, US
• Patrick Koch · Marlborough, US
• Rudy Schreiber · Menlo Park, US
• Kerry L. Spear · Oakland, US

Key dates

• Filing date: Jan 7, 2014
• Grant date: Mar 7, 2017
• Expiry date: Jan 7, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.