Preparation of (−)-huperzine A

US9586904B2 · kind B2 · utility

Assignee

• ZHEJIANG WANBANG PHARMACEUTICAL PLC. · CN

Inventors

• Shouming Zhao · Zhejiang, CN
• Ping Chen · Fujian, CN
• Shaoping Peng · Shanghai, CN
• Yinqiang Zhuang · Zhejiang, CN
• Rongzhen SHI · Zhejiang, CN
• Jinsheng Xie · Zhejiang, CN
• Weihua Xie · Zhejiang, CN

Key dates

• Filing date: Jun 17, 2014
• Grant date: Mar 7, 2017
• Expiry date: Jun 17, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for preparing (−)-huperzine A. The method involves: allowing a mixture of (±)-huperzine A obtained from chemical synthesis and a chiral acid to form (±)-huperzine A chiral acid salt under suitable conditions; recrystallizing the chiral acid salt from an organic solvent and basifying with an alkali to obtain optically pure (−)-huperzine A. The method is convenient to operate and suitable for industrial production. The chemical purity and optical purity of (−)-huperzine A obtained by the method are each greater than 99.5%, satisfying the requirement for raw pharmaceutical purity in the pharmaceutical industry.