Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof
US9586939B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 28, 2012 |
| Grant date | Mar 7, 2017 |
| Priority date | — |
| Expiry date | May 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a quinazoline derivative represented by the general formula (I), a pharmaceutical acceptable salt and a stereoisomer thereof as tyrosine kinase inhibitor, wherein R1, R2, R3, R3′, R4, R5, R6, X, L, T, Z and q are as defined in the specification. The invention also relates to a process for preparing the same, a pharmaceutical composition and a pharmaceutical formulation containing the derivative, use of the derivative for treating excessive proliferative diseases and chronic obstructive pulmonary disease and use of the derivative in the manufacture of a medicament for treating excessive proliferative diseases and chronic obstructive pulmonary disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.