Conjugated gold nanoparticles

US9587071B2 · kind B2 · utility

Assignees

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• IMRA America, Inc. · US

Inventors

• Duxin Sun · Ann Arbor, US
• Hongwei Chen · Hangzhou City, CN
• Wei Qian · Pittsburgh, US
• Yong Che · Ann Arbor, US
• Masayuki Ito · Sakado, JP
• Hayley Paholak · Ann Arbor, US
• Kanokwan Sansanaphongpricha · Ann Arbor, US

Key dates

• Filing date: Dec 8, 2015
• Grant date: Mar 7, 2017
• Expiry date: Dec 8, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0065
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).