Method of inducing homologous recombination of somatic cell
US9587251B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Dec 22, 2003 |
| Grant date | Mar 7, 2017 |
| Priority date | — |
| Expiry date | Dec 22, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/902
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a method for obtaining diverse novel genes by inducing somatic cell homologous recombination at genetic loci in somatic cells.By controlling transcription activity of a gene that exists at a genetic locus in a eukaryotic organism cell wherein DNA homologous recombination is occurring at an arbitrary genetic locus, somatic cell homologous recombination is induced between said gene and a gene having a DNA sequence similar to said gene that exists in a region upstream of a transcription promoter, whereby it is possible to obtain diverse novel genes having a plurality of genetic information.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.