Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
US9588129B2 · kind B2 · utility
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3References
14Claims
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Key dates
| Filing date | Mar 15, 2013 |
| Grant date | Mar 7, 2017 |
| Priority date | — |
| Expiry date | Mar 15, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/285
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of detecting a disease associated with abnormal protein aggregation in a subject is provided, the method comprising (a) contacting leukocytes from the subject with a probe that binds to pathogenic protein aggregates, and (b) detecting the probe bound to the pathogenic protein aggregates, wherein the presence of pathogenic protein aggregates in the leukocytes is indicative that the subject has a disease associated with abnormal protein aggregation. In one embodiment, the disease is Alzheimer's disease or mild cognitive impairment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.