Patent · US Active

Stable effervescent bisphosphonate formulations with rapid solubilization characteristics

US9592195B2 · kind B2 · utility

0Cited by

4References

15Claims

0Family size

Assignee

EffRx Pharmaceuticals SA · CH

Inventors

Marshall A. Hayward · Lawrenceville, US
Timo Schmidt · Stuttgart, DE

Key dates

Filing date	Dec 5, 2011
Grant date	Mar 14, 2017
Priority date	—
Expiry date	Dec 5, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P19/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.