Positron emission tomography probe to monitor selected sugar metabolism in vivo

US9592309B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Owen N. Witte · West Hollywood, US
• Peter M. Clark · Los Angeles, US
• Blanca Graciela Flores Castillo · San Fernando, US
• Michael E. Jung · Los Angeles, US
• Nikolai M. Evdokimov · Los Angeles, US

Key dates

• Filing date: May 9, 2013
• Grant date: Mar 14, 2017
• Expiry date: Jul 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.