Method for purifying protein complexes
US9593143B2 · kind B2 · utility
4Cited by
10References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2009 |
| Grant date | Mar 14, 2017 |
| Priority date | — |
| Expiry date | May 14, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.