Engineered polypeptides having enhanced duration of action
US9593154B2 · kind B2 · utility
2Cited by
14References
10Claims
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Key dates
| Filing date | Mar 28, 2013 |
| Grant date | Mar 14, 2017 |
| Priority date | — |
| Expiry date | Mar 28, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, short bowel syndrome, Parkinson's disease, cardiovascular disease, and other and disorders of the central nervous system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.