Differentiation of pluripotent stem cells
US9593306B2 · kind B2 · utility
3Cited by
76References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 2012 |
| Grant date | Mar 14, 2017 |
| Priority date | — |
| Expiry date | Jun 18, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.