Identification of antigen or ligand-specific binding proteins
US9593327B2 · kind B2 · utility
1Cited by
44References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 15, 2014 |
| Grant date | Mar 14, 2017 |
| Priority date | — |
| Expiry date | Oct 31, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B30/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.
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