Method for identifying biologically active oligonucleotides capable of modulating the immune system
US9593337B2 · kind B2 · utility
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31Claims
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Key dates
| Filing date | Aug 31, 2015 |
| Grant date | Mar 14, 2017 |
| Priority date | — |
| Expiry date | Aug 31, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/11
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods of identifying oligonucleotides capable of modulating the immune system in a mammalian subject, comprising analysis of which tertiary structural type said oligonucleotide adopts, in phosphate-buffered saline solution. Further, the invention provides oligonucleotides identifiable by the methods of the invention and to their use in methods of treating diseases, such as inflammatory diseases, autoimmune diseases, infectious diseases, neurodegenerative diseases and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.