Microfluidic devices for multiplexed electrochemical detection

US9594051B2 · kind B2 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• George M. Whitesides · Newton, US
• Xiujun Li · Seattle, US
• Frederique Deiss · Cambridge, US
• Zhihong Nie · Cambridge, US
• Xinyu Liu · Nanhu, CN

Key dates

• Filing date: Mar 6, 2014
• Grant date: Mar 14, 2017
• Expiry date: Apr 29, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/492
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The multiplexed electrochemical microfluidic paper-based analytical device comprises multiple detection zones for the detection of multiple biochemical analytes from one single sample. Cavity valves integrated on the device will deliver the sample to different detection zones. These analytes include, but are not limited to, urea, creatinine, creatine, glucose, lactate, ethanol, uric acid, cholesterol, pyruvate, creatinine, β-hydroxybutyrate, alanine aminotrasferase, aspartate aminotransferase, alkaline phosphatase, and acetylcholinesterase (or its inhibitors). This system will provide a simple and low-cost POC approach to obtain quantitative and multiple biological information from one sample (e.g. one drop of blood).