Patent · US Active

Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

US9597334B2 · kind B2 · utility

1Cited by

10References

40Claims

0Family size

Assignee

PLEDPHARMA AB · SE

Inventors

Jan-Olof Karlsson · Oslo, NO
Karl E. Reineke · Niskayuna, US
Tino Kurz · Säter, SE
Rolf Andersson · Vikingstad, SE
Michael Hall · Albany, US
Christina McLaughlin · Albany, US
Sven Jacobsson · Stockholm, SE
Jacques Näsström · Bromma, SE

Key dates

Filing date	Oct 26, 2015
Grant date	Mar 21, 2017
Priority date	—
Expiry date	Oct 26, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F19/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10:wherein X, R1, R2, R3, and R4 are as defined herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.