Fluorescent membrane intercalating probes and methods for their use
US9597416B2 · kind B2 · utility
0Cited by
9References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 23, 2014 |
| Grant date | Mar 21, 2017 |
| Priority date | — |
| Expiry date | Aug 13, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.