Polyamine transporter selective compounds as anti-cancer agents
US9598351B2 · kind B2 · utility
3Cited by
3References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 23, 2015 |
| Grant date | Mar 21, 2017 |
| Priority date | — |
| Expiry date | Sep 23, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.