Method for preparing a pyripyropene compound

US9598428B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Melanie Bonnekessel · Mannheim, DE
• Wolfgang Reichert · Bischofswerda, DE
• Ralf HOOCK · Ludwigshafen, DE
• Thomas Kaeding · Mannheim, DE
• Christopher Koradin · Ludwigshafen, DE
• Andreas Pletsch · Schifferstadt, DE
• Manfred Ehresmann · Ludwigshafen, DE
• Hartwig Schroeder · Greytown, ZA

Key dates

• Filing date: Jan 15, 2014
• Grant date: Mar 21, 2017
• Expiry date: Jan 15, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01N53/00
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).