Modified thymine polynucleotide oligomers and methods
US9598455B2 · kind B2 · utility
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119Claims
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Key dates
| Filing date | Mar 30, 2015 |
| Grant date | Mar 21, 2017 |
| Priority date | — |
| Expiry date | Apr 9, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2525/117
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are modified thymine bases that provide enhanced base-pairing affinity for adenine or 2,6-diaminopurine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified thymine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.