Nucleic acid molecules encoding muteins of human tear lipocalin which bind PCSK9

US9598476B2 · kind B2 · utility

Assignee

• DAIICHI SANKYO COMPANY, LIMITED · JP

Inventors

• Gabriele Matschiner · Munich, DE
• Christine Rothe · Freising, DE
• Andreas Hohlbaum · Paunzhausen, DE
• Andrea Allersdorfer · Wolnzach, DE
• Rachida Siham Bel Aiba · Munich, DE
• Marlon Hinner · Freising, DE
• Alexander Wiedenmann · Ulm, DE
• Bradley M. Lunde · Lebanon, US
• Shinji Yamaguchi · Shinagawa, JP
• Takahide Aburatani · Kashiwa, JP
• Ryuji Hashimoto · Tokyo, JP
• Tohru Takahashi · Tokyo, JP
• Chikako Nagasaki · Tokyo, JP
• Futoshi Nara · Yachiyo, JP
• Tomohiro Nishizawa · Tokyo, JP

Key dates

• Filing date: Aug 28, 2015
• Grant date: Mar 21, 2017
• Expiry date: Aug 28, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2121/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules.