Micro-RNAs involved in macular degeneration

US9598694B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• The Administrators of the Tulane Educational Fund · US

Inventors

• Shusheng Wang · New Orleans, US
• Eric Olson · Dallas, US
• Qinbo Zhou · Dallas, US

Key dates

• Filing date: May 2, 2013
• Grant date: Mar 21, 2017
• Expiry date: May 2, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3231
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the involvement of miR function in the development of age-related macular degeneration (AMD). It is shown that miR-23, miR-24 and/or miR-27 are involved in pathologic neovascularization in AMD, and that agonism (miR-24) and inhibition (miR23/27) of the function of these molecules blocks events contributing to development and progression of disease.