Recombinant bacterium to decrease tumor growth
US9598697B2 · kind B2 · utility
7Cited by
41References
18Claims
0Family size
Assignee
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Key dates
| Filing date | May 31, 2011 |
| Grant date | Mar 21, 2017 |
| Priority date | — |
| Expiry date | May 31, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A recombinant bacterium capable of reducing tumor growth is provided, wherein said recombinant bacterium is capable of: a. increased expression of a nucleic acid encoding a chemoreceptor that directs chemotaxis towards tumors, b. accumulation in a quiescent tumor, c. hyper-invasion of a tumor, d. reduced fitness in normal tissue, e. enhanced stimulation of the host innate immune responses, f. delivering a tumor specific DNA vaccine vector to a tumor cell, and g. increased bacterium-induced host programmed cell death.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.