Chemical process for preparing spiroindolones and intermediates thereof

US9598712B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Michael A. Crowe · Singapore, SG
• Michael Foulkes · Redwood City, US
• Giancarlo Francese · Basel, CH
• Dominique Grimler · Basel, CH
• Ernst Kuesters · Sankt Goarshausen, DE
• Kurt Laumen · Wuppertal, DE
• Yunzhong Li · 安丰镇, CN
• Changxue Lin · Hoherlehmer Straße, CN
• Jovana Nazor · Milpitas, US
• Thomas Ruch · Frenkendorf, CH
• Derek Smith · Singapore, SG
• Shiwei Song · Singapore, SG
• Shangjun Teng · Hoherlehmer Straße, CN

Key dates

• Filing date: Mar 22, 2013
• Grant date: Mar 21, 2017
• Expiry date: Mar 22, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.